Activated phenotype of circulating neutrophils in familial Mediterranean fever

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33143924" target="_blank" >RIV/61989592:15110/13:33143924 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.imbio.2012.10.007" target="_blank" >http://dx.doi.org/10.1016/j.imbio.2012.10.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.imbio.2012.10.007" target="_blank" >10.1016/j.imbio.2012.10.007</a>

Result language
angličtina
Original language name
Activated phenotype of circulating neutrophils in familial Mediterranean fever
Original language description
Familial Mediterranean fever (FMF) is autoinflammatory disorder, characterized by MEFV gene mutations and recurrent episodes of fever and serosal or synovial inflammation. Neutrophils are the predominant effector cells of acute inflammatory attacks in FMF; however pathogenic role and molecular phenotype of these cells remain largely unknown. To gain insight into the processes that contribute to the self-directed autoinflammation we characterized expression of a spectrum of genes involved in regulation of inflammation in unstimulated and LPS-activated neutrophils from FMF patients. Expression of 12 candidate immune genes encoding for inflammation-related molecules was assessed by quantitative RT-PCR in freshly isolated and LPS-stimulated peripheral polymorphonuclear neutrophils from fifteen FMF patients in attack-free period and ten healthy volunteers as controls. The relative expression was calculated using the second derivative method; the target gene expression was normalized to the
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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