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[(68)Ga]NS(3)-RGD and [(68)Ga] Oxo-DO3A-RGD for imaging alfa(v)beta(3) integrin expression: synthesis, evaluation, and comparison

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33145217" target="_blank" >RIV/61989592:15110/13:33145217 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.nucmedbio.2012.09.006" target="_blank" >http://dx.doi.org/10.1016/j.nucmedbio.2012.09.006</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.nucmedbio.2012.09.006" target="_blank" >10.1016/j.nucmedbio.2012.09.006</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    [(68)Ga]NS(3)-RGD and [(68)Ga] Oxo-DO3A-RGD for imaging alfa(v)beta(3) integrin expression: synthesis, evaluation, and comparison

  • Original language description

    Introduction: Ga-68-labeled RGD peptides in combination with PET allow non-invasive determination of alpha(v)beta(3) integrin expression which is highly increased during tumor-induced angiogenesis. The aim of this study was to synthesize and evaluate twoRGD peptides containing alternative chelating systems, namely [Ga-68]NS3-RGD and [Ga-68]Oxo-DO3A-RGD and to compare their in vitro and in vivo properties with [Ga-68]DOTA- and [Ga-68]NODAGA-RGD. Methods: Syntheses of both radiotracers followed standardSPPS protocols. For in vitro characterization distribution coefficients, protein binding abilities, serum stablities, and alpha(v)beta(3) integrin binding affinities were determined. For in vitro tests as well as for the biodistribution assay alpha(v)beta(3) positive human melanoma M21 and alpha(v)beta(3) negative M21-L cells were used. Results: Ga-68-labeling of NS3-RGD resulted in good radiochemical purity, whereas HPLC analysis showed two peaks with a ratio of 1:6 for [Ga-68]Oxo-DO3A-

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nuclear Medicine and Biology

  • ISSN

    0969-8051

  • e-ISSN

  • Volume of the periodical

    40

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    65-72

  • UT code for WoS article

    000312420000009

  • EID of the result in the Scopus database