[(68)Ga]NS(3)-RGD and [(68)Ga] Oxo-DO3A-RGD for imaging alfa(v)beta(3) integrin expression: synthesis, evaluation, and comparison
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33145217" target="_blank" >RIV/61989592:15110/13:33145217 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.nucmedbio.2012.09.006" target="_blank" >http://dx.doi.org/10.1016/j.nucmedbio.2012.09.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nucmedbio.2012.09.006" target="_blank" >10.1016/j.nucmedbio.2012.09.006</a>
Alternative languages
Result language
angličtina
Original language name
[(68)Ga]NS(3)-RGD and [(68)Ga] Oxo-DO3A-RGD for imaging alfa(v)beta(3) integrin expression: synthesis, evaluation, and comparison
Original language description
Introduction: Ga-68-labeled RGD peptides in combination with PET allow non-invasive determination of alpha(v)beta(3) integrin expression which is highly increased during tumor-induced angiogenesis. The aim of this study was to synthesize and evaluate twoRGD peptides containing alternative chelating systems, namely [Ga-68]NS3-RGD and [Ga-68]Oxo-DO3A-RGD and to compare their in vitro and in vivo properties with [Ga-68]DOTA- and [Ga-68]NODAGA-RGD. Methods: Syntheses of both radiotracers followed standardSPPS protocols. For in vitro characterization distribution coefficients, protein binding abilities, serum stablities, and alpha(v)beta(3) integrin binding affinities were determined. For in vitro tests as well as for the biodistribution assay alpha(v)beta(3) positive human melanoma M21 and alpha(v)beta(3) negative M21-L cells were used. Results: Ga-68-labeling of NS3-RGD resulted in good radiochemical purity, whereas HPLC analysis showed two peaks with a ratio of 1:6 for [Ga-68]Oxo-DO3A-
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nuclear Medicine and Biology
ISSN
0969-8051
e-ISSN
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Volume of the periodical
40
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
65-72
UT code for WoS article
000312420000009
EID of the result in the Scopus database
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