Mitochondrial Changes in Adenocarcinoma of the Pancreas

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33145430" target="_blank" >RIV/61989592:15110/13:33145430 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/01913123.2013.788306" target="_blank" >http://dx.doi.org/10.3109/01913123.2013.788306</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/01913123.2013.788306" target="_blank" >10.3109/01913123.2013.788306</a>

Result language
angličtina
Original language name
Mitochondrial Changes in Adenocarcinoma of the Pancreas
Original language description
The aim of your study was to analyse the mitochondrial ultrastructure in primary ductal adenocarcinomas of the pancreas and to compare it with normal pancreatic cells. 52 samples of adenocarcinoma of the pancreas obtained by surgical resection or by endosonographic biopsy were examined. Compared to normal mitochondrial ultrastructure in non -tumorous cells, the mitochondria in cancer cells had a dense matrix and condensed configuration or with lucent-swelling matrix associated with disarrangement and distortion of cristae and partial or total cristolysis. Functionally , these structural alterations presume the presence of hypoxia-tolerant and hypoxia-sensitive cencer cells.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NT11023" target="_blank" >NT11023: PET / CT and ultrastructural changes of mitochondria as predictive factors for pancreatic cancer</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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