STAT6 - polymorphisms, haplotypes and epistasis in relation to atopy and asthma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33145486" target="_blank" >RIV/61989592:15110/13:33145486 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/13:#0000530
Result on the web
<a href="http://dx.doi.org/10.5507/bp.2013.043" target="_blank" >http://dx.doi.org/10.5507/bp.2013.043</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2013.043" target="_blank" >10.5507/bp.2013.043</a>
Alternative languages
Result language
angličtina
Original language name
STAT6 - polymorphisms, haplotypes and epistasis in relation to atopy and asthma
Original language description
Background. STAT6 has an important role in the IL-4/IL-13 signalling pathway. Genome - wide association studies have shown that particular polymorphism (SNP) or haplorype variants of STAT6 as well as epigenetic gene modifications are associated with IgElevel and astma in childhood. Methods. A review of the available literature was performed to map out the function and signalling patway of STAT6, studies of STAT6 SNP s association with susceptibility to asthma and atopy, covering the years 1997 - 2012 were summarized, and the value of epigenetic and epistatic influences on STAT6 and their relevance to the development of the studiend phenotype (atopy or asthma) were determined. Results. There are 2 SNPs (rs71802646 and rs320411) with clinical association and proven functional effect on STAT6 expression. The effect of STAT6 SNPs cumulates in haplotypes and more potently during interaction with SNPs in the genes from the signallling pathway (IL4, IL4Ra, and IL13). Expression of STAT6 is o
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers-Olomouc
ISSN
1213-8118
e-ISSN
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Volume of the periodical
157
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
9
Pages from-to
172-180
UT code for WoS article
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EID of the result in the Scopus database
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