Expression of miR-15a and miR-16-1 in patients with chronic lymphocytic leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33145788" target="_blank" >RIV/61989592:15110/13:33145788 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/13:#0000578

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2013.057" target="_blank" >http://dx.doi.org/10.5507/bp.2013.057</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2013.057" target="_blank" >10.5507/bp.2013.057</a>

Result language

angličtina

Original language name

Expression of miR-15a and miR-16-1 in patients with chronic lymphocytic leukemia

Original language description

Introduction. MicroRNAs (miRNAs) are small non-coding single-stranded RNA molecules that regulate gene expression at the post-transcriptional level. In the pathogenesis of chronic lymphocytic leukemia (CLL), miR-15a and miR-16-1 play an important role. These miRNAs are located on chromosome 13 in the 13q14.3 region, which is deleted in more than 55% of CLL patients. This aberration affects expression of miRNAs. Objectives. The study aimed at performing a molecular genetic analysis of miR-15a and miR-16-1 expression in a group of 39 patients diagnosed with CLL and determining the association between the expression of the two miRNAs and types of deletions in the 13q14 region. Methods. We used fluorescence in situ hybridiziation (FISH) for determination of mono- or biallelic deletion 13q and quantitative polymerase chain reaction (Q-RT-PCR) to revealed expression miR-15a and miR-16-1 in 39 patients suffering from CLL. Results. The analysis comprised 19 patients with monoallelic 13q14 dele

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NT13576" target="_blank" >NT13576: Integrated genomic analysis of chronic lymphocytic leukemia (CLL) for genetic and clinical identification of subgroups with aberrations of selected chromosomes.</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

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Volume of the periodical

157

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

284-293

UT code for WoS article

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EID of the result in the Scopus database

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