MEG3: A novel long noncoding potentially tumour-suppressing RNA in meningiomas (Review)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33146092" target="_blank" >RIV/61989592:15110/13:33146092 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/13:#0000427

Result on the web

<a href="http://dx.doi.org/10.1007/s11060-012-1038-6" target="_blank" >http://dx.doi.org/10.1007/s11060-012-1038-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11060-012-1038-6" target="_blank" >10.1007/s11060-012-1038-6</a>

Result language

angličtina

Original language name

MEG3: A novel long noncoding potentially tumour-suppressing RNA in meningiomas (Review)

Original language description

Meningiomas represent one of the most common types of primary intracranial tumours. However, the specific molecular mechanisms underlying their pathogenesis remain uncertain. Loss of chromosomes 22q, 1p, and 14q have been implicated in most meningiomas.Inactivation of the NF2 gene at 22q12 has been identified as an early event in their pathogenesis, whereas abnormalities of chromosome 14 have been reported in higher-grade as well as recurrent tumours. It has long been supposed that chromosome 14q32 contains a tumour suppressor gene. However, the identity of the potential 14q32 tumour suppressor remained elusive until the Maternally Expressed Gene 3 (MEG3) was recently suggested as an ideal candidate. MEG3 is an imprinted gene located at 14q32 that encodes a non-coding RNA (ncRNA). In meningiomas, loss of MEG3 expression, its genomic DNA deletion and degree of promoter methylation have been found to be associated with aggressive tumour growth. These findings indicate that MEG3 may have

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neuro-Oncology

ISSN

0167-594X

e-ISSN

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Volume of the periodical

112

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

1-8

UT code for WoS article

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EID of the result in the Scopus database

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