Complement system in SLE as a target for antibodies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33146837" target="_blank" >RIV/61989592:15110/13:33146837 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/13:#0000483

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Complement system in SLE as a target for antibodies

Original language description

SLE is characterized by overproduction of various types of autoantibodies. Under certain circumstaces, antibodies targeting some of the neoepitopes of the complement system can be seen. The most studied among antibodies directed against a component of the complement system is anti-C1q. Anti-C1q antibodies are present in approximately one third of the patients with lupus, who often have high clinical disease activity and in particular renal involvement. In the presence of high titers of anti-C1q antibodies also the levels of C1q and C3 and C4 complements of the complement system are also usually low. The presence of the anti-C1q antibodies is not limited or specific just for SLE or lupus nephritis. For the first time, they were described in HUVS (Hypocomplementemic Urticarial Vasculitis Syndrome), later in Felty's syndrome, rheumatoid vasculitis, hepatitis C, poststreptococcal glomerulonephritis or aging population.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Rheumatology Reviews

ISSN

1573-3971

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

34-44

UT code for WoS article

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EID of the result in the Scopus database

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