Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33148411" target="_blank" >RIV/61989592:15110/14:33148411 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/aji.12203" target="_blank" >http://dx.doi.org/10.1111/aji.12203</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/aji.12203" target="_blank" >10.1111/aji.12203</a>
Alternative languages
Result language
angličtina
Original language name
Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women.
Original language description
Although sera and all external secretions contain antibodies to human immunodeficiency virus (HIV), their levels, specificity, isotypes, and relevant effector functions display a great degree of variability. Antibodies that bind HIV antigens and neutralize the virus are predominantly associated with the IgG isotype in sera and in all external secretions, even where total levels of IgG are much lower than those of IgA. Rectal fluid that contains high IgA, but low IgG levels, displayed low neutralizing activity independent of antibodies. Therefore, external secretions should be evaluated before and after selective depletion of Ig. At the systemic level, HIV-specific IgA may interfere with the effector functions of IgG, as suggested by recent studies of individuals systemically immunized with an experimental HIV vaccine. Although HIV-specific IgG and IgA antibodies may exhibit their protective activities at mucosal surfaces through interference with viral entry and local neutralization at
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Reproductive Immunology
ISSN
1046-7408
e-ISSN
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Volume of the periodical
71
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
600-607
UT code for WoS article
000335917600014
EID of the result in the Scopus database
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