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Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33148411" target="_blank" >RIV/61989592:15110/14:33148411 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1111/aji.12203" target="_blank" >http://dx.doi.org/10.1111/aji.12203</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/aji.12203" target="_blank" >10.1111/aji.12203</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women.

  • Original language description

    Although sera and all external secretions contain antibodies to human immunodeficiency virus (HIV), their levels, specificity, isotypes, and relevant effector functions display a great degree of variability. Antibodies that bind HIV antigens and neutralize the virus are predominantly associated with the IgG isotype in sera and in all external secretions, even where total levels of IgG are much lower than those of IgA. Rectal fluid that contains high IgA, but low IgG levels, displayed low neutralizing activity independent of antibodies. Therefore, external secretions should be evaluated before and after selective depletion of Ig. At the systemic level, HIV-specific IgA may interfere with the effector functions of IgG, as suggested by recent studies of individuals systemically immunized with an experimental HIV vaccine. Although HIV-specific IgG and IgA antibodies may exhibit their protective activities at mucosal surfaces through interference with viral entry and local neutralization at

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    American Journal of Reproductive Immunology

  • ISSN

    1046-7408

  • e-ISSN

  • Volume of the periodical

    71

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    600-607

  • UT code for WoS article

    000335917600014

  • EID of the result in the Scopus database