Gastrointestinal stromal tumour: From the clinic to the molecules

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33148908" target="_blank" >RIV/61989592:15110/14:33148908 - isvavai.cz</a>

Result on the web

<a href="http://nobleresearch.org/Journals/JCRT/Volume2/2052-4994-2014-8.aspx" target="_blank" >http://nobleresearch.org/Journals/JCRT/Volume2/2052-4994-2014-8.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14312/2052-4994.2014-8" target="_blank" >10.14312/2052-4994.2014-8</a>

Result language

angličtina

Original language name

Gastrointestinal stromal tumour: From the clinic to the molecules

Original language description

GastroIntestional stromal tumours (GISTs), the most frequent sarcoma in the gastro-intestinal (GI) tract, are highly resistant to conventional chemotherapy and radiotherapy. These tumours have activating mutations in two closely related genes, KIT (75-80%) or/and PDGFRA (5-10%). Targeting these mutated activated proteins with imatinib mesylate has proven efficient in the treatment of GISTs. The median survival after diagnosis of GIST increased from 1.5 to 4.8 years with imatinib treatment. However, resistance to imatinib eventually develops and new-targeted therapies are needed. This paper reviews the medical, clinical and pathological aspects of GISTs based on latest research in human cell lines and animal models.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cancer Research & Therapy

ISSN

2052-4994

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

54-67

UT code for WoS article

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EID of the result in the Scopus database

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