Chronic schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33148990" target="_blank" >RIV/61989592:15110/14:33148990 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S0165178114002261/1-s2.0-S0165178114002261-main.pdf?_tid=b1112514-7c79-11e4-93cf-00000aab0f6c&acdnat=1417782463_6680883a271d3ff12167660d94a0ec1b" target="_blank" >http://ac.els-cdn.com/S0165178114002261/1-s2.0-S0165178114002261-main.pdf?_tid=b1112514-7c79-11e4-93cf-00000aab0f6c&acdnat=1417782463_6680883a271d3ff12167660d94a0ec1b</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.psychres.2014.03.020" target="_blank" >10.1016/j.psychres.2014.03.020</a>

Result language
angličtina
Original language name
Chronic schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene
Original language description
Altered immune response, including low-grade inflammatory processes, is involved in the pathogenesis of schizophrenia, a chronic psychiatric disorder with complex etiology. Distinct gene variants of a number of pro-inflammatory and chemotactic cytokinestogether with their receptors associate with this disorder. Interleukin-2 receptor gamma (IL-2RG) represents an important signaling component of many interleukin receptors and so far, no data on the functional state of this receptor in schizophrenia havebeen reported. The aim of this study was to investigate mRNA expression of the IL2RG gene (IL2RG) in schizophrenia patients in comparison with healthy subjects (controls). Total RNA was isolated from peripheral blood of 66 schizophrenia patients and 99healthy subjects of Armenian population. The mRNA expression was determined by quantitative real-time polymerase chain reaction (RT-PCR) using PSMB2 as housekeeping gene. IL2RG mRNA expression was upregulated in peripheral blood of patien
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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