Comparison of periprosthetic tissues in knee and hip joints: differential expression of CCL3 and DC-STAMP in total knee and hip arthroplasty and similar cytokine profiles in primary knee and hip osteoarthritis.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33149400" target="_blank" >RIV/61989592:15110/14:33149400 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.joca.2014.08.004" target="_blank" >http://dx.doi.org/10.1016/j.joca.2014.08.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.joca.2014.08.004" target="_blank" >10.1016/j.joca.2014.08.004</a>

Result language
angličtina
Original language name
Comparison of periprosthetic tissues in knee and hip joints: differential expression of CCL3 and DC-STAMP in total knee and hip arthroplasty and similar cytokine profiles in primary knee and hip osteoarthritis.
Original language description
OBJECTIVE: To identify expression profiles (EP) associated with aseptic loosening of total knee arthroplasty (TKA) and to compare them with EP observed in total hip arthroplasty (THA), and primary hip and knee osteoarthritis. DESIGN: Gene EP of TNF, IL-6, IL-8, CHIT1, BMP4, CCL3, CCL18, MMP9, RANKL, OPG, DC-STAMP and SOCS3 were assessed using quantitative reverse transcriptase-polymerase chain reaction on tissues retrieved from patients with aseptically failed TKA (n=21), THA (n=41) and primary knee (n=20) and hip (n=17) osteoarthritis. Immunohistochemistry was applied to localize the proteins. RESULTS: When compared to knee osteoarthritis, the pseudosynovial tissues in TKA exhibit i) elevation of alternative macrophage activation marker (CHIT1), chemokine (IL-8), and a proteolytic enzyme (MMP9); ii) downregulation of pro-inflammatory cytokine (TNF), osteoclastic regulator (OPG) and a stimulator of bone formation (BMP4); iii) no difference in IL-6, CCL3, CCL18, RANKL, DC-STAMP and SOCS
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FI - Traumatology and orthopaedics
OECD FORD branch
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Project
<a href="/en/project/NT11049" target="_blank" >NT11049: Gene expression profiling of the periprosthetic tissues: first step toward time-dependent analysis of periprosthetic osteolysis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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