Intestinal permeability in patients with metastatic colon cancer treated with patupilone

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150508" target="_blank" >RIV/61989592:15110/14:33150508 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/14:10282938 RIV/00179906:_____/14:10282938

Result on the web

<a href="http://dx.doi.org/10.1515/cclm-2014-0096" target="_blank" >http://dx.doi.org/10.1515/cclm-2014-0096</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/cclm-2014-0096" target="_blank" >10.1515/cclm-2014-0096</a>

Result language

angličtina

Original language name

Intestinal permeability in patients with metastatic colon cancer treated with patupilone

Original language description

Background: Only a limited number of cytotoxic drugs have shown activity in metastatic colorectal carcinoma. Patupilone is a novel agent with promising activity in this common cancer. Diarrhea represents the dose-limiting toxicity of patupilone. Measurement of intestinal permeability is one of the potential methods of non-invasive laboratory assessment of gastrointestinal toxicity. Methods: We have assessed intestinal permeability by measuring absorption of lactulose, mannitol and xylose in 27 previously treated patients with metastatic colorectal cancer enrolled in a phase I trial of patupilone. Results: Lactulose/mannitol and lactulose/xylose ratios increased after the treatment. Significantly higher lactulose/ mannitol ratio was observed in patientswho had severe diarrhea. Moreover, patients who subsequently had an adverse event of grade 3 or higher had significantly higher baseline lactulose/mannitol or lactulose/xylose ratios. Conclusions: Measurement of intestinal permeability u

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Chemistry and Laboratory Medicine

ISSN

1434-6621

e-ISSN

—

Volume of the periodical

52

Issue of the periodical within the volume

11

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

1649-1655

UT code for WoS article

—

EID of the result in the Scopus database

—