Urinary Neopterin Concentrations During Combination Therapy with Cetuximab in Previously Treated Patients with Metastatic Colorectal Carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150510" target="_blank" >RIV/61989592:15110/14:33150510 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/14:10281532 RIV/00216208:11160/14:10281532 RIV/00179906:_____/14:10281532 RIV/00098892:_____/14:#0000745

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Urinary Neopterin Concentrations During Combination Therapy with Cetuximab in Previously Treated Patients with Metastatic Colorectal Carcinoma

Original language description

Background/Aim: Increased concentrations of neopterin, a biomarker of systemic immune response, have been reported after administration of cytokines, cytotoxic chemotherapy or external-beam radiation, but little is known about the effects of targeted-agents on neopterin. Patients and Methods: Urinary neopterin was studied in pre-treated patients with metastatic colorectal carcinoma during therapy with cetuximab, administered mostly in combination with irinotecan, 5-fluorouracil and leucovorin. Urinary neopterin was determined by high-performance liquid chromatography. Results: High initial urinary neopterin concentrations predicted poor prognosis. A significant correlation was observed between urinary neopterin and peripheral blood leukocyte count, hemoglobin and carcinoembryonic antigen concentrations. Urinary neopterin concentrations significantly increased during therapy only in patients with initially low neopterin concentrations. Conclusion: Urinary neopterin concentrations predic

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

In vivo

ISSN

0258-851X

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

5

Country of publishing house

GR - GREECE

Number of pages

7

Pages from-to

953-959

UT code for WoS article

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EID of the result in the Scopus database

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