FOLFOX/FOLFIRI pharmacogenetics: The call for a personalized approach in colorectal cancer therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150511" target="_blank" >RIV/61989592:15110/14:33150511 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/14:10281234 RIV/75010330:_____/14:00010436
Result on the web
<a href="http://dx.doi.org/10.3748/wjg.v20.i30.10316" target="_blank" >http://dx.doi.org/10.3748/wjg.v20.i30.10316</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3748/wjg.v20.i30.10316" target="_blank" >10.3748/wjg.v20.i30.10316</a>
Alternative languages
Result language
angličtina
Original language name
FOLFOX/FOLFIRI pharmacogenetics: The call for a personalized approach in colorectal cancer therapy
Original language description
While 5-fluorouracil used as single agent in patients with metastatic colorectal cancer has an objective response rate around 20%, the administration of combinations of irinotecan with 5-fluorouracil/folinic acid or oxaliplatin with 5-fluorouracil/folinic acid results in significantly increased response rates and improved survival. However, the side effects of systemic therapy such as myelotoxicity, neurotoxicity or gastrointestinal toxicity may lead to life-threatening complications and have a major impact on the quality of life of the patients. Therefore, biomarkers that would be instrumental in the choice of optimal type, combination and dose of drugs for an individual patient are urgently needed. The efficacy and toxicity of anticancer drugs in tumor cells is determined by the effective concentration in tumor cells, healthy tissues and by the presence and quantity of the drug targets. Enzymes active in drug metabolism and transport represent important determinants of the therapeuti
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
World Journal of Gastroenterology
ISSN
1007-9327
e-ISSN
—
Volume of the periodical
20
Issue of the periodical within the volume
30
Country of publishing house
CN - CHINA
Number of pages
15
Pages from-to
10316-10330
UT code for WoS article
—
EID of the result in the Scopus database
—