Isocitrate Dehydrogenase 1 and 2 Mutations in Gliomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150826" target="_blank" >RIV/61989592:15110/14:33150826 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jnr.23456" target="_blank" >http://dx.doi.org/10.1002/jnr.23456</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jnr.23456" target="_blank" >10.1002/jnr.23456</a>
Alternative languages
Result language
angličtina
Original language name
Isocitrate Dehydrogenase 1 and 2 Mutations in Gliomas
Original language description
Over the past few years, new biomarkers have allowed a deeper insight into gliomagenesis and facilitated the identification of possible targets for glioma therapy. Isocitrate dehydrogenase (IDH) 1 and IDH2 mutations have been shown to be promising biomarkers for monitoring disease prognosis and predicting the response to treatment. This review summarizes recent findings in this field. Web of Science, Science Direct, and PubMed online databases were used to search for publications investigating the roleof IDH in glioma. References were identified by searching for the keywords IDH1 or IDH2 and glioma and diagnostic or predictive or prognostic in papers published from January, 2008, to April, 2014. Only papers in English were reviewed. Publications available only as an abstract were not included. IDH1/2 mutations are tightly associated with grade II and III gliomas and secondary glioblastomas, with better prognosis and production of a recently described oncometabolite, 2-hydroxyglutarate
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF NEUROSCIENCE RESEARCH
ISSN
0360-4012
e-ISSN
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Volume of the periodical
92
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1611-1620
UT code for WoS article
000344004500002
EID of the result in the Scopus database
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