The effect of chelator type on in vitro receptor binding and stability in Lu-177-labeled cetuximab and panitumumab

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150923" target="_blank" >RIV/61989592:15110/14:33150923 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/14:10281947
Result on the web
<a href="http://dx.doi.org/10.1002/jlcr.3204" target="_blank" >http://dx.doi.org/10.1002/jlcr.3204</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jlcr.3204" target="_blank" >10.1002/jlcr.3204</a>

Result language
angličtina
Original language name
The effect of chelator type on in vitro receptor binding and stability in Lu-177-labeled cetuximab and panitumumab
Original language description
Monoclonal antibodies are used in the therapy of various diseases. Thanks to their high specific uptake in target tissues, these antibodies can be utilized in targeted radioimmunotherapy as carriers of radioisotopes to tumors. However, important characteristics of antibodies such as target binding and stability in the organism may be affected by various structural parameters. This study has focused on the potential influence of selected chelators on radiochemical quality and in vitro receptor binding capacity in two modified monoclonal antibodies-cetuximab and panitumumab, both ligands of the epidermal growth factor receptor (EGFR). These two antibodies were each coupled with three macrocyclic chelators (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-triazacyclononane-1,4,7-triacetic acid, and 3,6,9,15-tetraazabicyclo[9.3.1]-pentadeca-1(15),11,13-triene-4-(S)-(4-isothiocyanatobenzyl)-3,6,9-triacetic acid) and labeled with lutetium-177. The stability of the preparations
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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