UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150982" target="_blank" >RIV/61989592:15110/14:33150982 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.15252/embr.201438679" target="_blank" >http://dx.doi.org/10.15252/embr.201438679</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.15252/embr.201438679" target="_blank" >10.15252/embr.201438679</a>

Result language
angličtina
Original language name
UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells
Original language description
UBL5 is an atypical ubiquitin-like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre-mRNA splicing efficiency, leading to globally enhanced intron retention. Defective sister chromatid cohesion is a general consequence of dysfunctional pre-mRNA splicing, resulting from the selective downregulation of the cohesion protection factor Sororin. As the UBL5 yeast orthologue, Hub1, also promotes spliceosome functions, our results show that UBL5 plays an evolutionary conserved role in pre-mRNA splicing, the integrity of which is essential for the fidelity of chromosome segregation.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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