ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150987" target="_blank" >RIV/61989592:15110/14:33150987 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/14:00436138

Result on the web

<a href="http://dx.doi.org/10.1016/j.cell.2014.05.046" target="_blank" >http://dx.doi.org/10.1016/j.cell.2014.05.046</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cell.2014.05.046" target="_blank" >10.1016/j.cell.2014.05.046</a>

Result language

angličtina

Original language name

ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

Original language description

ATR controls chromosome integrity and chromatin dynamics. We have previously shown that yeast Mec1/ATR promotes chromatin detachment from the nuclear envelope to counteract aberrant topological transitions during DNA replication. Here, we provide evidence that ATR activity at the nuclear envelope responds to mechanical stress. Human ATR associates with the nuclear envelope during S phase and prophase, and both osmotic stress and mechanical stretching relocalize ATR to nuclear membranes throughout the cell cycle. The ATR-mediated mechanical response occurs within the range of physiological forces, is reversible, and is independent of DNA damage signaling. ATR-defective cells exhibit aberrant chromatin condensation and nuclear envelope breakdown. We propose that mechanical forces derived from chromosome dynamics and torsional stress on nuclear membranes activate ATR to modulate nuclear envelope plasticity and chromatin association to the nuclear envelope, thus enabling cells to cope with

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell

ISSN

0092-8674

e-ISSN

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Volume of the periodical

158

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

633-646

UT code for WoS article

000340944300015

EID of the result in the Scopus database

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