RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33151198" target="_blank" >RIV/61989592:15110/14:33151198 - isvavai.cz</a>
Result on the web
<a href="http://www.bloodjournal.org/content/123/3/391?sso-checked=true" target="_blank" >http://www.bloodjournal.org/content/123/3/391?sso-checked=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/blood-2013-10-534222" target="_blank" >10.1182/blood-2013-10-534222</a>

Result language
angličtina
Original language name
RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling
Original language description
Overexpression of transcription factors RUNX1 and NF-E2 was reported in granulocytes of patients with polycythemia vera and other myeloproliferative neoplasms (MPN). We report that RUNX1 and NF-E2 overexpression is not specific for MPN because it was notdetected in patients with EPO receptor (EPOR) mutations, suggesting distinct mechanisms by which erythroid progenitors in polycythemias with defects of hypoxia sensing and EPOR mutations exert their EPO-hypersensitivity.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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