Somatic mutation in acute myelogenous leukemia cells imitate novel germline HLA-A allele: a case report
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33151990" target="_blank" >RIV/61989592:15110/14:33151990 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/14:#0000798
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/tan.12362/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/tan.12362/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/tan.12362" target="_blank" >10.1111/tan.12362</a>
Alternative languages
Result language
angličtina
Original language name
Somatic mutation in acute myelogenous leukemia cells imitate novel germline HLA-A allele: a case report
Original language description
A somatic mutation of the human leukocyte antigen (HLA)-A gene revealed in tumour cells of acute myelogenous leukemia (AML) is described. A patient with AML and her siblings were routinely typed for HLA in order to find a suitable donor for haematopoietic stem cell transplantation. Sequencing-based typing of the initial patient's sample characterized by high proportion of blasts revealed unknown G/A exchange at position 781 of the HLA-A gene (exon 4) associated with HLA-A*02:01 allele. Importantly, thisG781A variant was completely absent in the patient's remission sample obtained after the clearance of blasts. Our results are a reminder that HLA mutations in tumour cells may interfere with routine HLA typing and should always be considered, namely, inpatients with haematological malignancies.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Tissue Antigens
ISSN
0001-2815
e-ISSN
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Volume of the periodical
83
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
414-417
UT code for WoS article
000335836100007
EID of the result in the Scopus database
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