Tau protein, beta-amyloid(1-42) and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33152696" target="_blank" >RIV/61989592:15110/14:33152696 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/14:33152696
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0022510X14003566#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0022510X14003566#</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jns.2014.05.052" target="_blank" >10.1016/j.jns.2014.05.052</a>

Result language
angličtina
Original language name
Tau protein, beta-amyloid(1-42) and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia
Original language description
Background: Parkinson's disease (PD), PD with dementia (PDD) and Lewy body dementia (DLB) are synucleinopathies. PDD and DLB are sometimes considered a transition between PD and Alzheimer dementia (AD). Finding in vivo markers or their combination couldhelp in the differential diagnosis of these neurodegenerative (ND) diseases. Objective: The aim of this study was to assess cerebrospinal fluid (CSF) levels of tau protein, betaamyloid(1-42) and clusterin and to compare these levels among patients with probable PD, PDD, DLB and AD. Methods: CSF levels of ND markers were assessed in 96 patients (27 patients with PD, 14 with PDD, 14 with DLB, 17 with AD and 24 subjects as a control group). Results: In all of the groups of patients, beta-amyloid(1-42) levels were decreasing in the order PD } PDD } DLB } AD, whereas tau protein and the tau protein/beta-amyloid(1-42) index were increasing in the same order (PD { PDD { AD), except for DLB. In paired group comparisons, higher levels of cluster
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—

Project
<a href="/en/project/NT12221" target="_blank" >NT12221: Markers of neurodegeneration in differential diagnosis of parkinsonian syndrome</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)