Acute promyelocytic leukemia successfully treated also in elderly patients with significant comorbidities: a 20-year single-center experience

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33150782" target="_blank" >RIV/61989592:15110/15:33150782 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/15:#0000898

Result on the web

<a href="http://dx.doi.org/10.4149/neo_2015_019" target="_blank" >http://dx.doi.org/10.4149/neo_2015_019</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2015_019" target="_blank" >10.4149/neo_2015_019</a>

Result language

angličtina

Original language name

Acute promyelocytic leukemia successfully treated also in elderly patients with significant comorbidities: a 20-year single-center experience

Original language description

Acute promyelocytic leukemia is a unique entity among acute leukemias. Introduction of all-trans retinoic acid and, subsequently, arsenic trioxide in its treatment has markedly improved treatment outcomes for this once frequently fatal disease. Improvedoutcomes have also been observed in elderly patients, including those in whom standard intensive therapy is contraindicated because of comorbidities. In our center, a total of 60 APL patients were treated in 1993-2013, of whom 9 were aged 60 or more years. Although most of them had significant comorbidities at the time of diagnosis, eight achieved complete remission. At the time of the analysis, six patients were alive and in long-term remission; two patients died of causes other than APL. The median follow-up was 59 months. Included is case report of a patient with a high comorbidity score whose treatment was markedly reduced and individualized. Our experience shows that, in APL patients a curative approach is generally tolerated and s

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

6

Pages from-to

146-151

UT code for WoS article

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EID of the result in the Scopus database

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