Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33154502" target="_blank" >RIV/61989592:15110/15:33154502 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/15:00455894 RIV/00159816:_____/15:00063271 RIV/00216224:14310/15:00100428
Result on the web
<a href="http://dx.doi.org/10.18632/oncotarget.5392" target="_blank" >http://dx.doi.org/10.18632/oncotarget.5392</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.18632/oncotarget.5392" target="_blank" >10.18632/oncotarget.5392</a>

Result language
angličtina
Original language name
Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells
Original language description
Plasticity of cancer cells, manifested by transitions between epithelial and mesenchymal phenotypes, represents a challenging issue in the treatment of neoplasias. Both epithelial-mesenchymal transition (EMT) and mesenchymalepithelial transition (MET) are implicated in the processes of metastasis formation and acquisition of stem cell-like properties. Mouse double minute (MDM) 2 and MDMX are important players in cancer progression, as they act as regulators of p53, but their function in EMT and metastasis may be contradictory.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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