Positive Effects of Different Drug Forms of Silybin in the Treatment of Metabolic Syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33155785" target="_blank" >RIV/61989592:15110/15:33155785 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/15:00059591

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Positive Effects of Different Drug Forms of Silybin in the Treatment of Metabolic Syndrome

Original language description

Silymarin and silybin are widely used for their hepatoprotective properties. Our previous studies confirm positive effect of silymarin on lipoprotein profile and lipid homeostasis. Advanced drug forms may improve the bioavailability of these compounds. In this study, we investigate the effects of silybin in different drug forms (standardized silybin, micronized silybin, and silybin in form of phytosomes) on dyslipidemia and glucose metabolism in hereditary hypertriglyceridemic (HHTg) rats. Male HHTg rats were divided into four groups of seven animals and were fed by experimental diets. Silybin significantly decreased serum level of triglycerides in groups of rats fed by standardized silybin and silybin in form of phytosomes compared to control group. Results show that silybin did not affect the total cholesterol level, but significantly increased the levels of HDL cholesterol in all groups of animals. Silybin in a standardized form had the highest hypotriglyceridemic effect. On the oth

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/GA13-10813S" target="_blank" >GA13-10813S: Natural polyphenolic substances in experimental pharmacology of metabolic syndrome</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research (print)

ISSN

0862-8408

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

S4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

"S507"-"S512"

UT code for WoS article

000367548600009

EID of the result in the Scopus database

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