A dataset of 26 candidate gene and pro-inflammatory cytokine variants for association studies in idiopathic pulmonary fibrosis: frequency distribution in normal Czech population

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33156197" target="_blank" >RIV/61989592:15110/15:33156197 - isvavai.cz</a>
Result on the web
<a href="http://journal.frontiersin.org/article/10.3389/fimmu.2015.00476/full" target="_blank" >http://journal.frontiersin.org/article/10.3389/fimmu.2015.00476/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2015.00476" target="_blank" >10.3389/fimmu.2015.00476</a>

Result language
angličtina
Original language name
A dataset of 26 candidate gene and pro-inflammatory cytokine variants for association studies in idiopathic pulmonary fibrosis: frequency distribution in normal Czech population
Original language description
Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive fibrosing interstitial pneumonia with poor diagnosis and a median survival of 2-3 years from initial diagnosis. The cellular inflammation drives the fibrotic response in lungand plays a major role in IPF pathogenesis. Inflammatory cells (majorly, type 2 alveolar epithelial cells) release TGF-?, the key mediator of pulmonary fibrosis, that regulates several profibrotic cytokines/chemokines, their receptors, receptor subunits,and growth factors inducing process of epithelial-mesenchymal transition (EMT). Among the pro-inflammatory and profibrotic cytokines involved in IPF pathogenesis, interleukin (IL)-1, IL-1?, IL-4, IL-5, IL-6R?, angiogenic IL-8/CXCL-8, IL-13, its receptorIL-13 R?2, and IL-33 have been implicated in accelerated inflammation and irreversible damage to lung architecture with loss of alveolar-capillary barrier basal membrane leading to persistent fibrosis. Genes encoding these factors exhibi
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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