Effect of Combining Ivabradine and ?-Blockers: Focus on the Use of Carvedilol in the SHIFT Population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33157491" target="_blank" >RIV/61989592:15110/15:33157491 - isvavai.cz</a>

Result on the web

<a href="http://Effect" target="_blank" >http://Effect</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000380812" target="_blank" >10.1159/000380812</a>

Result language

angličtina

Original language name

Effect of Combining Ivabradine and ?-Blockers: Focus on the Use of Carvedilol in the SHIFT Population

Original language description

OBJECTIVES: We explored the prescription of ?-blockers with ivabradine in patients with systolic heart failure, focusing on the most frequently coprescribed ?-blocker, carvedilol. METHODS: We analyzed outcomes in SHIFT patients with systolic heart failure who were prescribed ?-blockers (carvedilol, bisoprolol, metoprolol, or nebivolol) with ivabradine or placebo. Analysis was by intention to treat in patients prescribed a ?-blocker at the time of the event. RESULTS: Data were available for 2,596 patients receiving carvedilol, 1,483 bisoprolol, 1,424 metoprolol, and 197 nebivolol. Mean treatment duration was 19 months. There was no difference in the effect of ivabradine on the primary composite endpoint of cardiovascular death or heart failure hospitalization between the various ?-blockers [hazard ratios (HR) for risk reduction, 0.75-0.89; p for interaction=0.86]. Patients prescribed carvedilol with ivabradine had lower rates of primary composite endpoint (HR 0.80, 95% CI: 0.68-0.94), h

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cardiology

ISSN

0008-6312

e-ISSN

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Volume of the periodical

131

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

218-224

UT code for WoS article

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EID of the result in the Scopus database

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