The Relationship of MiR-21, MiR-126 and MiR-205 to P-Glycoprotein, MRP1 and LRP/MVP in Non-Small Cell Lung Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33163168" target="_blank" >RIV/61989592:15110/15:33163168 - isvavai.cz</a>
Result on the web
<a href="http://austinpublishinggroup.com/cancer-clinical-research/fulltext/cancer-v2-id1042.php" target="_blank" >http://austinpublishinggroup.com/cancer-clinical-research/fulltext/cancer-v2-id1042.php</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The Relationship of MiR-21, MiR-126 and MiR-205 to P-Glycoprotein, MRP1 and LRP/MVP in Non-Small Cell Lung Cancer
Original language description
Protein transporters P-gp, MRP1 and LRP/MVP participate in the emergence of multidrug resistance (MDR) in non-small cell lung cancer (NSCLC). Their expression is post-transcriptionally regulated by microRNAs (miRNAs). Dysregulation of miR-21, miR-126 and miR-205 is often found in NSCLC. The aim of this study was to determine whether the level of miRNAs is associated with expression of the above mentioned proteins involved in MDR and whether they can be used as prognostic and diagnostic markers. We analysed miR-21, miR-126 and miR-205 in various histological subtypes of NSCLC. Their expression was then correlated with clinico-pathological characteristics, such as progression free survival (PFS), overall survival (OS) and different histological subtypes of NSCLC and, with expression of P-gp, MRP1 and LRP/MVP. We found no significant relationship between miR-21 and miR-126 expression and clinico-pathological parameters. However, miR- 205 levels were significantly increased in squamous cell carcinomas (p<10-6) compared with other histological subtypes of NSCLC. Additionally, the level of miR-205 inversely correlated with P-gp expression in NSCLC patients (p=0.03). Results of this study suggest that miR-205 could be used as a diagnostic marker and its downregulation may indicate the emergence of P-gp mediated drug resistance in NSCLC patients.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Austin Journal of Cancer and Clinical Research
ISSN
2381-909X
e-ISSN
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Volume of the periodical
2
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
"1042-1"-"1042-6"
UT code for WoS article
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EID of the result in the Scopus database
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