Synthesis of 3a-deuterated 7a-hydroxy-DHEA and 7-oxo-DHEA and application in LC-MS/MS plasma analysis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33159162" target="_blank" >RIV/61989592:15110/16:33159162 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/16:33159162
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0039128X16300332" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039128X16300332</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2016.05.001" target="_blank" >10.1016/j.steroids.2016.05.001</a>

Result language
angličtina
Original language name
Synthesis of 3a-deuterated 7a-hydroxy-DHEA and 7-oxo-DHEA and application in LC-MS/MS plasma analysis
Original language description
7-Oxygenated metabolites of dehydroepiandrosterone (DHEA) are known for their neuroprotective and immunomodulatory properties. These neuroactive steroids are currently predominately analysed by mass spectrometry, for which the use of internal deuterated standards is necessary. The aim of this study was to synthesize the deuterated derivatives of 7a-hydroxy-DHEA and 7-oxo-DHEA and test them in liquid chromatography-tandem mass spectrometry (LC-MS/MS) in order to enhance the performance characteristics of this method.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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