Prolonged response to pemetrexed-based chemotherapy in a patient with peritoneal mesothelioma: a case report and review of the literature

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33160404" target="_blank" >RIV/61989592:15110/16:33160404 - isvavai.cz</a>

Result on the web

<a href="https://www.degruyter.com/downloadpdf/j/pteridines.2016.27.issue-1-2/pterid-2015-0015/pterid-2015-0015.pdf" target="_blank" >https://www.degruyter.com/downloadpdf/j/pteridines.2016.27.issue-1-2/pterid-2015-0015/pterid-2015-0015.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/pterid-2015-0015" target="_blank" >10.1515/pterid-2015-0015</a>

Result language

angličtina

Original language name

Prolonged response to pemetrexed-based chemotherapy in a patient with peritoneal mesothelioma: a case report and review of the literature

Original language description

Peritoneal mesothelioma is a rare tumor typically presenting with ascites and associated with occupational asbestos exposure with a latency period of 20-40 years. Intensive multi-modality approach combining cytoreductive surgery, intraperitoneal chemotherapy and possibly radiotherapy can be considered, but otherwise the prognosis is rather poor. Palliative chemotherapy may be an option in these rare cases. However, no approved systemic treatment exists for peritoneal mesothelioma. We present here a patient with peritoneal mesothelioma who was treated with the combination of pemetrexed with cisplatin shortly after the failure of hyperthermic intraperitoneal chemotherapy. The patient experienced durable partial response to the treatment, resolution of ascites, and returned to his normal daily life activities. With the exception of palliative chemotherapy in case of patients in good condition, therapeutic options in patients with peritoneal mesothelioma are currently very limited. The combination of pemetrexed and cisplatin can lead to long-term control in selected patients.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pteridines

ISSN

0933-4807

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

1-2

Country of publishing house

DE - GERMANY

Number of pages

5

Pages from-to

1-5

UT code for WoS article

000377578800001

EID of the result in the Scopus database

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