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The serum expression of selected miRNAs in pulmonary sarcoidosis with/without Löfgren's syndrome

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33160597" target="_blank" >RIV/61989592:15110/16:33160597 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.hindawi.com/journals/mi/2016/1246129/" target="_blank" >https://www.hindawi.com/journals/mi/2016/1246129/</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2016/1246129" target="_blank" >10.1155/2016/1246129</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The serum expression of selected miRNAs in pulmonary sarcoidosis with/without Löfgren's syndrome

  • Original language description

    Abstract Purpose. Pulmonary sarcoidosis is associated with dysregulated expression of intracellular miRNAs. There is however only little information on extracellular miRNAs and their association with the disease course in sarcoidosis. We therefore assessed serum miRNAs in sarcoidosis classified according to the presence of Löfgren's syndrome (LS) as a hallmark of good prognosis in contrast to more advanced disease course. Methods. RT-PCR was used to assess 35 miRNAs in 13 healthy controls and 24 sarcoidosis patients (12 with X-ray (CXR) stage LESS-THAN OR EQUAL TO 1 and LS and 12 with insidious onset and CXR stage GREATER-THAN OR EQUAL TO 3). Results. Compared to controls, we consistently observed dysregulated expressions of miR-146, miR-16, miR-425-5p, and miR-93-5p in both sarcoidosis groups irrespective of disease course. Specifically, patients without LS had dysregulated expressions of miR-150-5p, miR-1, and miR-212 compared to controls. Patients with LS had dysregulated expressions of miR-21-5p and miR-340-5p compared to controls. Bioinformatics predicted consistently "Pathways in cancer" to be modulated by both altered profiles in patients with/without LS. Three miRNAs (miR-21-5p, miR-340-5p, and miR-212-3p) differed between our patients with LS and those without LS; their cumulative effect may modulate "TGF-β signalling pathway." Conclusions. Further study should focus on possible applications of serum miRNAs for diagnostics follow-up and for prognosis.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Mediators of Inflammation

  • ISSN

    0962-9351

  • e-ISSN

  • Volume of the periodical

    2016

  • Issue of the periodical within the volume

    1246129

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    "1246129-1"-"1246129-12"

  • UT code for WoS article

    000390462000001

  • EID of the result in the Scopus database

    2-s2.0-85008946375