The serum expression of selected miRNAs in pulmonary sarcoidosis with/without Löfgren's syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33160597" target="_blank" >RIV/61989592:15110/16:33160597 - isvavai.cz</a>
Result on the web
<a href="https://www.hindawi.com/journals/mi/2016/1246129/" target="_blank" >https://www.hindawi.com/journals/mi/2016/1246129/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2016/1246129" target="_blank" >10.1155/2016/1246129</a>
Alternative languages
Result language
angličtina
Original language name
The serum expression of selected miRNAs in pulmonary sarcoidosis with/without Löfgren's syndrome
Original language description
Abstract Purpose. Pulmonary sarcoidosis is associated with dysregulated expression of intracellular miRNAs. There is however only little information on extracellular miRNAs and their association with the disease course in sarcoidosis. We therefore assessed serum miRNAs in sarcoidosis classified according to the presence of Löfgren's syndrome (LS) as a hallmark of good prognosis in contrast to more advanced disease course. Methods. RT-PCR was used to assess 35 miRNAs in 13 healthy controls and 24 sarcoidosis patients (12 with X-ray (CXR) stage LESS-THAN OR EQUAL TO 1 and LS and 12 with insidious onset and CXR stage GREATER-THAN OR EQUAL TO 3). Results. Compared to controls, we consistently observed dysregulated expressions of miR-146, miR-16, miR-425-5p, and miR-93-5p in both sarcoidosis groups irrespective of disease course. Specifically, patients without LS had dysregulated expressions of miR-150-5p, miR-1, and miR-212 compared to controls. Patients with LS had dysregulated expressions of miR-21-5p and miR-340-5p compared to controls. Bioinformatics predicted consistently "Pathways in cancer" to be modulated by both altered profiles in patients with/without LS. Three miRNAs (miR-21-5p, miR-340-5p, and miR-212-3p) differed between our patients with LS and those without LS; their cumulative effect may modulate "TGF-β signalling pathway." Conclusions. Further study should focus on possible applications of serum miRNAs for diagnostics follow-up and for prognosis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mediators of Inflammation
ISSN
0962-9351
e-ISSN
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Volume of the periodical
2016
Issue of the periodical within the volume
1246129
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"1246129-1"-"1246129-12"
UT code for WoS article
000390462000001
EID of the result in the Scopus database
2-s2.0-85008946375