Fused Ring Molecular Scaffold with 3D Architecture for Constrained Peptidomimetics: Polymer-Supported Stereoselective Synthesis of Tetrahydrobenzo[e]pyrazinothiadiazinone 6,6-dioxide via N-Acyl Iminiums
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33160874" target="_blank" >RIV/61989592:15110/16:33160874 - isvavai.cz</a>
Result on the web
<a href="http://pubs.acs.org/doi/ipdf/10.1021/acscombsci.6b00126" target="_blank" >http://pubs.acs.org/doi/ipdf/10.1021/acscombsci.6b00126</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acscombsci.6b00126" target="_blank" >10.1021/acscombsci.6b00126</a>
Alternative languages
Result language
angličtina
Original language name
Fused Ring Molecular Scaffold with 3D Architecture for Constrained Peptidomimetics: Polymer-Supported Stereoselective Synthesis of Tetrahydrobenzo[e]pyrazinothiadiazinone 6,6-dioxide via N-Acyl Iminiums
Original language description
3,4,4a,5-Tetrahydrobenzo[e]pyrazinothiadiazin-1(2H)-one 6,6-dioxides, molecular scaffolds with 3D architecture, were synthesized on a solid support via tandem N-acyl iminium ion cyclization followed by nucleophilic addition. The modular synthesis proceeded under mild conditions using commercially available building blocks and provided crude products with respectable purity. Synthesized compounds are applicable as fused nitrogenous heterocyclic compounds in drug discovery as well as constrained peptidomimetics incorporated into peptide backbone.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Combinatorial Science
ISSN
2156-8952
e-ISSN
—
Volume of the periodical
18
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
655-659
UT code for WoS article
—
EID of the result in the Scopus database
—