Synthesis of a Small Library of Imidazolidin-2-ones using Gold Catalysis on Solid Phase

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33160888" target="_blank" >RIV/61989592:15110/16:33160888 - isvavai.cz</a>
Result on the web
<a href="http://pubs.acs.org/doi/ipdf/10.1021/acscombsci.6b00062" target="_blank" >http://pubs.acs.org/doi/ipdf/10.1021/acscombsci.6b00062</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acscombsci.6b00062" target="_blank" >10.1021/acscombsci.6b00062</a>

Result language
angličtina
Original language name
Synthesis of a Small Library of Imidazolidin-2-ones using Gold Catalysis on Solid Phase
Original language description
An efficient and high-yielding solid phase synthesis of a small library of imidazolidin-2-ones and imidazol-2-ones was carried out employing a high chemo- and regioselective gold-catalyzed cycloisomerization as a key step. Polymer-supported amino acids derivatized with several alkyne functionalities combined with tosyl- and phenylureas have been subjected to gold-catalysis exhibiting exclusively CMINUS SIGN N bond formation. The present work proves the potential of solid phase synthesis and homogeneous gold catalysis as an efficient and powerful synthetic tool for the generation of drug-like heterocycles.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/EE2.3.30.0004" target="_blank" >EE2.3.30.0004: POST-UP</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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