18F-fluorodeoxyglucose and 18F-flumazenil positron emission tomography in patients with refractory epilepsy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33161726" target="_blank" >RIV/61989592:15110/16:33161726 - isvavai.cz</a>
Result on the web
<a href="https://www.degruyter.com/downloadpdf/j/raon.2016.50.issue-3/raon-2016-0032/raon-2016-0032.pdf" target="_blank" >https://www.degruyter.com/downloadpdf/j/raon.2016.50.issue-3/raon-2016-0032/raon-2016-0032.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/raon-2016-0032" target="_blank" >10.1515/raon-2016-0032</a>
Alternative languages
Result language
angličtina
Original language name
18F-fluorodeoxyglucose and 18F-flumazenil positron emission tomography in patients with refractory epilepsy
Original language description
Background. Epilepsy is a neurological disorder characterized by epileptic seizures as a result of excessive neuronal activity in the brain. Approximately 65 million people worldwide suffer from epilepsy; 20-40% of them are refractory to medication therapy. Early detection of disease is crucial in the management of patients with epilepsy. Correct localization of the ictal onset zone is associated with a better surgical outcome. The modern non-invasive techniques used for structural-functional localization of the seizure focus includes electroencephalography (EEG) monitoring, magnetic resonance imaging (MRI), single photon emission tomography/computed tomography (SPECT/CT) and positron emission tomography/computed tomography (PET/CT). PET/CT can predict surgical outcome in patients with refractory epilepsy. The aim of the article is to review the current role of routinely used tracer 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) as well as non routinely used 18F-Flumazenil (18F-FMZ) tracers PET/CT in patients with refractory epilepsy. Conclusions. Functional information delivered by PET and the morphologic information delivered by CT or MRI are essential in presurgical evaluation of epilepsy. Nowadays 18F-FDG PET/CT is a routinely performed imaging modality in localization of the ictal onset zone in patients with refractory epilepsy who are unresponsive to medication therapy. Unfortunately, 18F-FDG is not an ideal PET tracer regarding the management of patients with epilepsy: areas of glucose hypometabolism do not correlate precisely with the proven degree of change within hippocampal sclerosis, as observed by histopathology or MRI. Benzodiazepine-receptor imaging is a promising alternative in nuclear medicine imaging of epileptogenic focus. The use of 11C-FMZ in clinical practice has been limited by its short half-life and necessitating an on-site cyclotron for production. Therefore, 18F-FMZ might be established as one of the tracers of choice....
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Radiology and Oncology
ISSN
1318-2099
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
3
Country of publishing house
SI - SLOVENIA
Number of pages
7
Pages from-to
247-253
UT code for WoS article
000382261600001
EID of the result in the Scopus database
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