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Perilipin-2: A new prospective biomarker for the diagnosis of acute myocardial ischemia

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33161910" target="_blank" >RIV/61989592:15110/16:33161910 - isvavai.cz</a>

  • Result on the web

    <a href="https://oatext.com/pdf/JTS-2-155.pdf" target="_blank" >https://oatext.com/pdf/JTS-2-155.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.15761/JTS.1000155" target="_blank" >10.15761/JTS.1000155</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Perilipin-2: A new prospective biomarker for the diagnosis of acute myocardial ischemia

  • Original language description

    Many scientists have been looking for faster, more accurate and confirmatory biomarkers of acute myocardial infarction (AMI). The aim has been to investigate an assay for the determination of perilipin-2 in human serum, and to check its clinical relevance as a marker of acute myocardial infarction (AMI First type). We have analytically and clinically examined a sandwich ELISA for perilipin-2 measurement. The Perilipin-2 serum level did not differentiate between men and women, but individuals with AMI showed to have higher concentrations of this marker. Perilipin-2 correlated with the serum TNF-α, ultra-sensitive (us) CRP, cystatinC and negatively with Apolipoprotein A1, HDL cholesterol and adiponectin. Using ROC analysis, it was found that the diagnostic efficiency of perilipin-2 was (excellent) and significantly higher than the others. We conclude that perilipin-2 is a very promising biomarker for the diagnosis of acute coronary syndrome.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Translational Science

  • ISSN

    2059-268X

  • e-ISSN

  • Volume of the periodical

    2

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    4

  • Pages from-to

    297-300

  • UT code for WoS article

  • EID of the result in the Scopus database