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Heterogeneity of Aberrant O-Glycosylation of IgA1 in IgA Nephropathy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33162268" target="_blank" >RIV/61989592:15110/16:33162268 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1007/978-4-431-55588-9" target="_blank" >http://dx.doi.org/10.1007/978-4-431-55588-9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/978-4-431-55588-9" target="_blank" >10.1007/978-4-431-55588-9</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Heterogeneity of Aberrant O-Glycosylation of IgA1 in IgA Nephropathy

  • Original language description

    IgA nephropalhy, a frequent cause of end-stage renal disease, is an autoimmune disease wherein immune complexes consisting of IgA1 with galaclose-deficient O-glycans and anti-glycan autoantibodies deposit in the glomeruli and induce renal injury. Serum IgA1 has three to six clustered O-glycans, some of which may be deficient in galactose and thus expose terminal or sialylated N-acetylgalactoseamine. Patients with IgAN usually have elevated serum levels of Gd-lgA1. The mechanism involved in production of Gd-lgA1 is not fully understood.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Pathogenesis and treatment in IgA Nephropathy

  • ISBN

    978-4-431-55587-2

  • Number of pages of the result

    16

  • Pages from-to

    53-68

  • Number of pages of the book

    342

  • Publisher name

    Springer Japan KK

  • Place of publication

    Tokio

  • UT code for WoS chapter