Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33162825" target="_blank" >RIV/61989592:15110/16:33162825 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/16:00460868 RIV/61388963:_____/16:00460868
Result on the web
<a href="http://biomed.papers.upol.cz/pdfs/bio/2016/02/07.pdf" target="_blank" >http://biomed.papers.upol.cz/pdfs/bio/2016/02/07.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2016.013" target="_blank" >10.5507/bp.2016.013</a>

Result language
angličtina
Original language name
Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs
Original language description
The archetypal DNA methyltransferase inhibitors, 5-azacytidine (AZA) and 5-aza-2'-deoxycytidine (DAC) are potent antineoplastic agents used in the treatment of mainly, blood malignancies. However, the administration of these drugs is confounded by their hydrolytic lability which decreases plasma circulation time. Here, we describe a new biodegradable, polyanhydride formulation for drug delivery that circumvents this drawback.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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