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Cranberry Intervention in Patients with Localized Prostate Cancer prior to Radical Prostatectomy.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A73579414" target="_blank" >RIV/61989592:15110/16:73579414 - isvavai.cz</a>

  • Alternative codes found

    RIV/00098892:_____/16:N0000081

  • Result on the web

    <a href="http://dx.doi.org/10.5507/bp.2016.048" target="_blank" >http://dx.doi.org/10.5507/bp.2016.048</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5507/bp.2016.056" target="_blank" >10.5507/bp.2016.056</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cranberry Intervention in Patients with Localized Prostate Cancer prior to Radical Prostatectomy.

  • Original language description

    Background and Objectives. Recently, we described an inverse association between cranberry supplementation and serum prostate specific antigen (PSA) in patients with negative biopsy for prostate cancer (PCa) and chronic nonbac- terial prostatitis. This double blind placebo controlled study evaluates the effects of cranberry consumption on PSA values and other markers in men with PCa before radical prostatectomy. Methods. Prior to surgery, 64 patients with prostate cancer were randomized to a cranberry or placebo group. The cranberry group (n=32) received a mean 30 days of 1500 mg cranberry fruit powder. The control group (n=32) took a similar amount of placebo. Selected blood/urine markers as well as free and total phenolics in urine were measured at baseline and on the day of surgery in both groups. Prostate tissue markers were evaluated after surgery. Results. The serum PSA significantly decreased by 22.5% in the cranberry arm (n=31, P&lt;0.05). A trend to down-regula- tion of urinary beta-microseminoprotein (MSMB) and serum gamma-glutamyltranspeptidase, as well as upregulation of IGF-1 was found after cranberry supplementation. There were no changes in prostate tissue markers or, composition and concentration of phenolics in urine. Conclusions. Daily consumption of a powdered cranberry fruit lowered serum PSA in patients with prostate cancer. The whole fruit contains constituents that may regulate the expression of androgen-responsive genes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomedical Papers-Olomouc

  • ISSN

    1213-8118

  • e-ISSN

  • Volume of the periodical

    160

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    7

  • Pages from-to

    559-565

  • UT code for WoS article

    000392810500017

  • EID of the result in the Scopus database