Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A73582078" target="_blank" >RIV/61989592:15110/16:73582078 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/15:#0000942

Result on the web

<a href="http://biomed.papers.upol.cz/artkey/bio-201602-0008_Characterization_of_iron_metabolism_and_erythropoiesis_in_erythrocyte_membrane_defects_and_thalassemia_traits.php" target="_blank" >http://biomed.papers.upol.cz/artkey/bio-201602-0008_Characterization_of_iron_metabolism_and_erythropoiesis_in_erythrocyte_membrane_defects_and_thalassemia_traits.php</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits

Original language description

Background and Aims: Erythropoiesis is closely related to iron metabolism in a balanced homeostasis. Analyses of diverse erythroid and iron metabolism disorders have shown that disrupted erythropoiesis negatively affects iron homeostasis and vice versa. The aim of this study was to characterize the relationship between erythropoietic activity and iron homeostasis in pediatric patients with erythrocyte membrane defects and thalassemia traits. Methods: Selected markers of erythropoietic activity (erythropoietin, soluble transferrin receptor - sTfR and growth differentiation factor 15) and iron status parameters (serum iron, ferritin and hepcidin) were evaluated in pediatric patients with erythrocyte membrane defects and thalassemia traits. Results: The patients with erythrocyte membrane defects and thalassemia traits had altered iron homeostasis due to disturbed erythropoiesis. In comparison with healthy controls, they had a normal to low hepcidin/ferritin ratio and concomitantly elevated sTfR. Conclusion: The findings suggest that pediatric patients with erythrocyte membrane defects and thalassemia traits are more susceptible to iron overload than the general population and that the (hepcidin/ferritin)/sTfR ratio can be used to monitor any worsening of the disease.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30209 - Paediatrics

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

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Volume of the periodical

160

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

231-237

UT code for WoS article

000379360500008

EID of the result in the Scopus database

2-s2.0-84976340219