Apolipoprotein B vs non-high-density lipoprotein cholesterol: Association with endothelial hemostatic markers and carotid intima-media thickness

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73580527" target="_blank" >RIV/61989592:15110/17:73580527 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.jacl.2017.01.020" target="_blank" >http://dx.doi.org/10.1016/j.jacl.2017.01.020</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jacl.2017.01.020" target="_blank" >10.1016/j.jacl.2017.01.020</a>

Result language

angličtina

Original language name

Apolipoprotein B vs non-high-density lipoprotein cholesterol: Association with endothelial hemostatic markers and carotid intima-media thickness

Original language description

Blackground: both apolipoprotein B (apoB) and non-high-density lipoprotein cholesterol (non-HDL-C) are accepted as alternative risk factors or targets for lipid-lowering therapy, which correlate more strongly with cardiovascular events than low-denstiy lipoprotein cholestrerol. Objective:the aim of this cross-sectional study was to evaluate the differences in plasma levels of plasminogen activator inhibitor-1 (PAI-1) and of von WIllebrand factor (vWF) as endothelial hemostatik markers and carotid intima-media thickness (C-IMT) as a morpholigic marker for atherosclerotic vascular disease among dyslipidemic individuals with apoB levels higher, estimated or lower based on regression equation of apoB vs non-HDL-C. Methods: a total of 594 dyslipidemic subjects without atherosclerotic manifestation were divided into 3 groups (according to tertiles of apB levels above, within, and below the line of identity): H-apoB (n = 200), E-apoB (n = 194), and L-apoB (n = 200). PAI-1, vWF, C-IMT and lipids, anthropometric parameters, markers of isulin resistence, and inflammation were measured. DIfferences in variables between groups were analyzed using analysis of variance. Reults: there was a strong association between apoB and non-HDL-C. The correlations of apoB and of non-HDL-C with markers of endothelial damage and C-IMT were very similar. Despite these facts, individuals with higher apoB levels had significantly higher levels of PAI-I compared with individuals with estimated (P &lt; 0,05) or lower apoB (P &lt; 0,001). There were no significant differences in vWF, C-IMT, markers of insulin resistance, obesity, and inflammation. Conclusion: Individuals with apoB higher than predicted by non-HDL-C had significantly higher levels of PAI-1, which may contribute to the increased risk of future atherothrombotic events.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Lipidology

ISSN

1933-2874

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

442-449

UT code for WoS article

000402346500017

EID of the result in the Scopus database

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