Inverse association of lipoprotein (a) with markers of insulin resistance in dyslipidemic subjects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73580720" target="_blank" >RIV/61989592:15110/17:73580720 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/17:N0000040

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Inverse association of lipoprotein (a) with markers of insulin resistance in dyslipidemic subjects

Original language description

Lipoprotein (a) [Lp(a)] is an LDL-like particle that contains an apolipoprotein B100 molecule covalently bound to a plasminogen-like glycoprotein, apolipoprotein (a) [apo(a)]. Epidemiological evidence supports a direct and causal association between Lp(a) levels and coronary risk. On the contrary, a few prospective findings demonstrate inverse association of Lp(a) levels with risk of type 2 diabetes (T2DM). The aim of our study was to evaluate the association of Lp(a) with indicators of insulin resistence (IR) and metabolic syndrome (MS), which precede development of T2DM. We enrolled 607 asymptomatic dyslipidemic subjects (295 men and 312 women, mean age 45.6±14.0 years) into our cross-sectional study. Lp(a) concentrations correlated inversely with TG, AIP, insulin, HOMA, C-peptide, BMI, waist circumference, and number of MS components (p&lt;0.01 for all). Subjects with MS had significantly lower Lp(a) in the lower (1th-3rd) quartiles of insulin and HOMA were significantly higher than in the 4th quartile of these insulin resistance markers (p&lt;0.001). Odds ratios of having increased markers of IR (TG, HOMA) and MS in top quartile of Lp(a) also indicate inverse association of Lp(a) with IR. The results of our study support an inverse association of Lp(a) levels with IR and MS that precedes overt T2DM diagnosis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research (print)

ISSN

0862-8408

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

suppl. 1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

"S113"-"S120"

UT code for WoS article

000398620900013

EID of the result in the Scopus database

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