Role of strontium ranelate in the therapy of osteoporosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73580907" target="_blank" >RIV/61989592:15110/17:73580907 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/17:N0000085
Result on the web
<a href="http://dx.doi.org/10.23937/2469-5726/1510050" target="_blank" >http://dx.doi.org/10.23937/2469-5726/1510050</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.23937/2469-5726/1510050" target="_blank" >10.23937/2469-5726/1510050</a>
Alternative languages
Result language
angličtina
Original language name
Role of strontium ranelate in the therapy of osteoporosis
Original language description
Strontium ranelate is a medicine used to treat postmenopausal osteoporosis in women and osteoporosis in men. Preclinical data suggest its dual effect consisting of the control of bone resorption and promotion of bone formation. Admininstration of strontium ranelate leads to significant increase in the bone mass. Changes in bone density can be used to evaluate the adherence of patients as well as, in case of strontium ranelate, to etimate the fracture risk reduction. Clinical studies demonstrated its effect on reducing the risk of both vertebral and non-vertebral fractures, including fractures of the proximal femur. Currently, it is a second-line treatment of osteoporosis administered in case of intolerance, failure or contraindication of other therapy. Recently its cardiovascular safety was discussed. Contraindications of strontium ranelate in patients with ischemic heart disease, peripheral arterial desease, cerebrovascular disease or uncontrolled hypertension were added in 2013 to the wording of the Summary of Product Characteristics (SPC). Cohort and observational studies, however, did not clearly confirm the cardiovascular risk associated with administration of strontium ranelate. It is still a medicine indicated for treatment of osteoporosis with a favourable risk and benefit ratio.
Czech name
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Czech description
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Classification
Type
J<sub>ost</sub> - Miscellaneous article in a specialist periodical
CEP classification
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OECD FORD branch
30218 - General and internal medicine
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Rheumatic Diseases and Treatment
ISSN
2469-5726
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
1-6
UT code for WoS article
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EID of the result in the Scopus database
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