CD38-negative relapse in multiple myeloma after daratumumab-based chemotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73581186" target="_blank" >RIV/61989592:15110/17:73581186 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/17:N0000015
Result on the web
<a href="http://dx.doi.org/10.1111/ejh.12902" target="_blank" >http://dx.doi.org/10.1111/ejh.12902</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ejh.12902" target="_blank" >10.1111/ejh.12902</a>
Alternative languages
Result language
angličtina
Original language name
CD38-negative relapse in multiple myeloma after daratumumab-based chemotherapy
Original language description
Abstract We present a case report of a patient relapsing after anti-CD38 treatment (daratumumab). The phenotype of the disease changed during this treatment, and the myeloma clone became CD38 negative and daratumumab refractory. We expected clonal shift, however, based on immunophenotyping, cytogenetics and arrayCGH; the clone was identical as before daratumumab-based treatment with the exception of CD38 negativity. We suggest that the downregulation or loss of CD38 might be an epigenetic "escape mechanism" of malignant plasma cells from antibody-based treatment. The aim of our study was to point out the pitfalls of immunophenotyping and cytogenetics in both assessing the minimal residual disease and clone detection after monoclonal antibody-based therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Haematology
ISSN
0902-4441
e-ISSN
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Volume of the periodical
99
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
186-189
UT code for WoS article
000404936400010
EID of the result in the Scopus database
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