Mixed-phenotype acute leukemia: state-of-the-art of the diagnosis,
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73582129" target="_blank" >RIV/61989592:15110/17:73582129 - isvavai.cz</a>
Result on the web
<a href="http://biomed.papers.upol.cz/artkey/bio-201703-0002_mixed-phenotype_acute_leukemia_state-of-the-art_of_the_diagnosis_classification_and_treatment.php" target="_blank" >http://biomed.papers.upol.cz/artkey/bio-201703-0002_mixed-phenotype_acute_leukemia_state-of-the-art_of_the_diagnosis_classification_and_treatment.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2017.013" target="_blank" >10.5507/bp.2017.013</a>
Alternative languages
Result language
angličtina
Original language name
Mixed-phenotype acute leukemia: state-of-the-art of the diagnosis,
Original language description
Mixed-phenotype acute leukemia (MPAL) is a heterogeneous group of hematopoietic malignancies in which blasts show markers of multiple developmental lineages and cannot be clearly classified as acute myeloid or lymphoblastic leukemias. Historically, various names and classifications were used for this rare entity accounting for 2-5% of all acute leukemias depending on the diagnostic criterias used. The currently valid classification of myeloid neoplasms and acute leukemia published by the World Health Organization (WHO) in 2016 refers to this group of diseases as MPAL. Because adverse cytogenetic abnormalities are frequently present, MPAL is generally considered a disease with a poor prognosis. Knowledge of its treatment is limited to retrospective analyses of small patient cohorts. So far, no treatment recommendations verified by prospective studies have been published. The reported data suggest that induction therapy for acute lymphoblastic leukemia followed by allogeneic hematopoietic cell transplantation is more effective than induction therapy for acute myeloid leukemia or consolidation chemotherapy. The establishment of cooperative groups and international registries based on the recent WHO criterias are required to ensure further progress in understanding and treatment of MPAL. This review summarizes current knowledge on the diagnosis, classification, prognosis and treatment of MPAL patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers-Olomouc
ISSN
1213-8118
e-ISSN
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Volume of the periodical
161
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
234-241
UT code for WoS article
000418004800002
EID of the result in the Scopus database
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