Androgen Receptor as a Target for Epigenetic Therapy of Castration Resistant Prostate Cancer (CRPC)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73582371" target="_blank" >RIV/61989592:15110/17:73582371 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Androgen Receptor as a Target for Epigenetic Therapy of Castration Resistant Prostate Cancer (CRPC)
Original language description
Androgen and androgen receptor play key roles in the development of the prostate gland as well as the prostate cancer. Evidence from basic research and clinical studies indicates that androgen receptor and AR-dependent transcription remain activate in castration resistant prostate cancer. Alterations in the androgen receptor signaling axis are central to castration resistant prostate cancer progression, and have uncovered complex mechanisms by which AR and other components of the AR signaling axis affect, and are affected by different type of coregulatory proteins as well as epigenetic modifications such as DNA methylation and enzymes effecting histone modifications.
Czech name
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Czech description
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Project
<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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