Possible interaction between mycophenolate mofetil and tacrolimus in kidney transplant patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73582488" target="_blank" >RIV/61989592:15110/17:73582488 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/17:73582488 RIV/00098892:_____/17:N0000072
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Possible interaction between mycophenolate mofetil and tacrolimus in kidney transplant patients
Original language description
Tacrolimus is the mainstay of transplant immunosuppression in kidney graft recipients. It is most commonly used in combination with mycophenolate mofetil. Literature data on the existence and significance of drug-drug interaction of these two drugs is contradictory and inconclusive for kidney transplant patients. The aim of the study was to confirm and quantify the interaction in kidney transplant patients.Based on our analysis, the interaction between mycophenolate mofetil and tacrolimus reported previously in liver transplant patients is present in kidney transplant patients as well. After prospective validation, a pharmacokinetic model could be used to predict tacrolimus level changes following adjustment of mycophenolate mofetil doses.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Klinická farmakologie a farmacie
ISSN
1212-7973
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
3-6
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85037368091