Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73583638" target="_blank" >RIV/61989592:15110/17:73583638 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10366274 RIV/61989592:15310/17:73583638
Result on the web
<a href="http://dx.doi.org/10.1038/nature25016" target="_blank" >http://dx.doi.org/10.1038/nature25016</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/nature25016" target="_blank" >10.1038/nature25016</a>

Result language
angličtina
Original language name
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Original language description
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing. Here we highlight the potential for repurposing disulfiram (also known by the trade name Antabuse), an old alcohol-aversion drug that has been shown to be effective against diverse cancer types in preclinical studies.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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