Possibilities for modifying risk factors for the development of hospital-acquired pneumonia in intensive care patients: results of a retrospective, observational study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73584233" target="_blank" >RIV/61989592:15110/17:73584233 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2017.019" target="_blank" >http://dx.doi.org/10.5507/bp.2017.019</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2017.019" target="_blank" >10.5507/bp.2017.019</a>

Result language

angličtina

Original language name

Possibilities for modifying risk factors for the development of hospital-acquired pneumonia in intensive care patients: results of a retrospective, observational study

Original language description

Background. Hospital-acquired pneumonia (HAP) development is affected by a range of risk factors. Methods. A retrospective, observational study processing data on all consecutive intensive care patients older than 18 years of age between 1 January 2011 and 31 December 2015. The aim was to determine the incidence of potential risk factors and their impact on the development of HAP. Results. A total of 2229 patients. The overall mortality was 24.0%; the mean APACHE II score 21.4. The mean length of ICU stay was 5.9 days and the mean length of hospital stay was 20.5 days. The criteria for HAP were met by 310 patients (13.9%). Early- and late-onset HAP was diagnosed in 45 (14.5%) and 265 (85.5%) patients, respectively. The mean APACHE II score was 22.1, the mean length of ICU stay was 7.6 days and the mean length of hospital stay was 23.5 days. The most important non-modifiable factors increasing the risk of HAP were multiple organ failure (OR 13.733; P&lt;0.0001), cardiac heart disease (OR 2.255; P&lt;0.0001) and chronic renal failure (OR 2.194; P&lt;0.002). The most common modifiable factors were intolerance to enteral nutrition (OR 3.055; P&lt;0.0001), urgent tracheal intubation (OR 1.511; P&lt;0.024), reintubation (OR 1.851; P&lt;0.001), and bronchoscopy (OR 2.558; P&lt;0.0001). Stress ulcer prophylaxis was administered to 83% of HAP patients and 68% of patients without HAP. Prophylaxis with famotidine was associated with a lower risk of HAP in 40.0% of patients (non-HAP in 49.9%), (OR 0.669; P=0.001) than prophylaxis with pentoprazol in 42.6% and 49.5% of patients, respectively (OR 0.756; P=0.027). Conclusions. Factors associated with the highest risk of the development of HAP can be determined. Pharmacological prophylaxis of gastric and duodenal stress ulcers was identified as an independent risk factor for HAP. The study was registered in the ClinicalTrials.gov database under the number NCT02779933.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30223 - Anaesthesiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

—

Volume of the periodical

161

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

303-309

UT code for WoS article

000418004800010

EID of the result in the Scopus database

2-s2.0-85030211190