Uptake of 18F-FET and 18F-FCH in human glioblastoma T98G cell line after irradiation with photons or carbon ions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73584673" target="_blank" >RIV/61989592:15110/17:73584673 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2017/6491674" target="_blank" >http://dx.doi.org/10.1155/2017/6491674</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2017/6491674" target="_blank" >10.1155/2017/6491674</a>
Alternative languages
Result language
angličtina
Original language name
Uptake of 18F-FET and 18F-FCH in human glioblastoma T98G cell line after irradiation with photons or carbon ions
Original language description
The differential diagnosis between recurrence of gliomas or brain metastases and this phenomenon is important in order to choose the best therapy and predict the prognosis but is still a big problem for physicians.The new emerging MRI, CT, and PET diagnostic modalities still lack sufficient accuracy. Radiolabeled choline and amino acids have been reported to show great tumor specificity. We studied the uptake kinetics of [18F]fluoromethyl-choline (FCH) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) by the T98G human glioblastoma cells from 20 to 120 min after irradiation either with photons at 2-10-20Gy or with carbon ions at 2 Gy (at the National Centre for Oncological Hadrontherapy (CNAO), Pavia, Italy).We also evaluated the cell death and morphology changes induced by radiation treatment. Both FET and FCH are able to trace tumor behavior in terms of higher uptake for increased doses of radiation treatment, due to the upregulation of cells attempts to repair nonlethal damage. Our data suggest that both FCH and FET could be useful to analyze the metabolic pathways of glioblastoma cells before and after radiotherapy. Physicians will have to consider the different kinetics pathways of uptake concerning the two radiopharmaceuticals.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Contrast Media and Molecular Imaging
ISSN
1555-4309
e-ISSN
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Volume of the periodical
2017
Issue of the periodical within the volume
2017
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
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UT code for WoS article
000399198100001
EID of the result in the Scopus database
2-s2.0-85014332280