Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73584733" target="_blank" >RIV/61989592:15110/17:73584733 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/17:N0000102
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2468024917303005?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2468024917303005?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ekir.2017.07.002" target="_blank" >10.1016/j.ekir.2017.07.002</a>
Alternative languages
Result language
angličtina
Original language name
Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy
Original language description
IgA nephropathy is a chronic renal disease characterized by mesangial immunodeposits that contain autoantigen, which is aberrantly glycosylated IgA1 with some hinge-region O-glycans deficient in galactose. Macroscopic hematuria during an upper respiratory tract infection is common among patients with IgA nephropathy, which suggests a connection between inflammation and disease activity. Interleukin-6 (IL-6) is an inflammatory cytokine involved in IgA immune response. We previously showed that IL-6 selectively increases production of galactose-deficient IgA1 in IgA1-secreting cells from patients with IgA nephropathy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/NV15-33686A" target="_blank" >NV15-33686A: The study of the relation between Epstein-Barr virus infection and development of IgA nephropathy</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Kidney International Reports
ISSN
2468-0249
e-ISSN
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Volume of the periodical
2
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
1194-1207
UT code for WoS article
000418639800022
EID of the result in the Scopus database
2-s2.0-85040709658