METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73586840" target="_blank" >RIV/61989592:15110/17:73586840 - isvavai.cz</a>

Result on the web

<a href="https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20170823&DB=EPODOC&locale=en_EP&CC=EP&NR=2068882B1&KC=B1&ND=4" target="_blank" >https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20170823&DB=EPODOC&locale=en_EP&CC=EP&NR=2068882B1&KC=B1&ND=4</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION

Original language description

The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water- insoluble terpenoid having a free carboxylic functional group is derivatized on this functional group with a substituent selected from the group comprising quarternary ammonium substituents of general formula Xb bound to the carboxy group of the terpenoid, wherein Xb is - (CH2)n N+R3-, quarternary ammonium substituents of general formula Xc bound to the carboxy group of the terpenoid, wherein Xc je -(CH2)nR+Y-, glycosylic substituents Xe bound by a or J3 glycosidic bond to the carboxy group of the terpenoid, wherein Xe is selected from the group comprising glucosyl, galactosyl, arabinosyl, rhamnosyl, lacyosyl, cellobiosyl, maltosyl and the 2-deoxyanalogues thereof, and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid,containing an inclusion complex of the derivatized pentacyclic or tetra-cyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation.

Czech name

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Czech description

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Type

P - Patent

CEP classification

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OECD FORD branch

10401 - Organic chemistry

Project

<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Patent/design ID

EP2068882

Publisher

EPO_1 -

Publisher name

European Patent Office

Place of publication

Munich, The Hague, Berlin, Vienna, Brussels

Publication country

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Date of acceptance

Aug 23, 2017

Owner name

Univerzita Karlova v Praze, Přírodovědecká fakulta; Univerzita Palackého v Olomouci; I.Q.A. a.s.

Method of use

A - Výsledek využívá pouze poskytovatel

Usage type

P - Využití výsledku jiným subjektem je v některých případech možné bez nabytí licence